Order 151 Appendix 3. List of vehicles provided to the armed forces of the Russian Federation, other troops, military formations and bodies, as well as special formations created for wartime. I. General provisions

30.03.2020

To increase the therapeutic effect, combined preparations with Amlodipine are prescribed.

You need to take the drug with extreme caution, in compliance with medical recommendations, as there are complications.

stable type;
vasospastic angina;
heart failure;
ischemic conditions;
bronchial asthma.

Patients are wondering if Amlodipine should be taken before or after meals. In fact, there is no difference, since the process of digestion of food does not affect the absorption of the components of the drug.

The drug retains the pharmacological effect for a long time, so you need to know whether to take Amlodipine in the morning or in the evening.

Definitely, you need to drink tablets at night, only once a day. With special care, the drug is prescribed to patients with low body weight, and to persons with renal insufficiency. The initial dosage for these groups should be below the standard rate, the rate is increased gradually.

With arterial hypertension, the remedy must be combined with, and,. In angina pectoris conditions, amlodipine can be prescribed both as an independent therapeutic drug, and in combination with other angina medicines.

When taking medication, body weight may change, this parameter should be controlled. At the time of treatment, you need to minimize the rate. Patients are shown a salt-free diet. You also need to avoid taking.

Elderly people, patients with insufficient body weight and short stature should undergo therapy under the close supervision of a specialist.

Dosage

You will have to start exposure to the drug with a minimum dosage. In the absence of side effects, you need to increase the dose to the maximum threshold. So, the drug is intended for internal use.

Amlodipine tablets

For hypertension, 2.5 mg is prescribed for elderly patients and people with low body weight. Standard dose for healthy person- 5 mg. A single dose of tablets is provided. When necessary, the patient switches to a dosage of 10 mg. You can do this after 7-10 days from the beginning of the course.

With angina pectoris, therapy begins with a dosage of 5 mg, with a progressive increase to 10 mg. One-time reception of means is appointed. The dosage is determined individually, based on age, body weight, general condition of the body and the severity of the disease.

For people with renal insufficiency, the drug is prescribed in a standard dosage.

The change in the norm does not affect the severity of the insufficiency.

Amlodipine is not excreted during dialysis. Other renal diseases are an indication for reducing the daily volume of the drug. Patients with such ailments are prescribed 2.5 mg. When it is necessary to strengthen the diuretic abilities of the body, the rate is increased to 5 mg.

When combining Amlodipine with beta-blockers, diuretic diuretics, ACE inhibitors, dosage adjustment is not necessary.

Overdose

An overdose of the drug is manifested. Against the background of vasodilation, a decrease may occur.

Patients also experience perfusion of internal organs. Prolonged provokes shock, even death.

In order to avoid negative consequences, there is no need to delay resuscitation measures. First aid is to wash the stomach. The patient must take sorbents. After that, the patient is recommended to be put in a horizontal position, it is better to raise the legs.

You need to carefully monitor your breathing and heart rate. In this situation, doctors prescribe cleansing procedures, hemodialysis, the introduction of Mezaton and Dopamine.

Against the background of discontinuation of the drug, the patient's condition may deteriorate sharply, the pressure may increase.

Interaction

The hypotensive, antianginal effect of the drug is enhanced when it is combined with the following groups of drugs:

antianginal agents, including Preductal, Riboxin;
medicines for kidney failure -,;
blockers of the "beta" type, including celiprolol;
neuroleptic compounds: Olanzapine, Droperidrol;
diuretic group: , Xipamide;
sympathomimetics, including Salbutamol, Isoprenaline.

Non-steroidal anti-inflammatory drugs, especially indomethacin, reduce the antianginal effect by inhibiting the synthesis of prostaglandins in the kidneys.

A joint multiple intake of Amlodipine (10 mg) with Simvastatin (80 mg) is practiced. At the same time, there is an increase in the impact of the latter by 77%, in contrast to monotherapy with it. Therefore, it is necessary to limit the daily dose of this agent to the norm of 20 mg for persons taking Amlodipine.

Side effects

Even though the drug is well received, there are certain side effects from the medication.

Amlodipine is a drug that can have a negative effect on different parts of the body:

the cardiovascular system. The patient develops shortness of breath and possibly a decrease in blood pressure and the appearance of hypotension. More often manifests itself and. Less rarely, symptoms such as migraine and vasculitis, heart failure and rhythm disturbances appear. Tachycardia may develop,;
nervous system. Violations manifest themselves and increased fatigue, drowsiness, nervousness and anxiety. The patient may also be accompanied by such conditions as depression and confusion, apathy and amnesia are much less common;
digestive department. Reactions such as dryness of the oral mucosa and constipation or diarrhea, pain in the abdominal region and flatulence are possible. Much less often, but such deviations may occur - anorexia, gastritis, pancreatitis, unreasonably high appetite;
genitourinary region. Deviations in this department caused by taking Amlodipine are rare. They are manifested by frequent urge to urinate, dysuria;
skin. In rare cases, manifestation of dermatitis and S. Johnson's syndrome, urticaria and xeroderma is possible. In this case, the photosensitivity of the skin also increases;
allergic type reactions. Skin rashes and itching, less often an angioedema reaction in the form of edema may occur in a patient on the drug;
locomotor apparatus. Prolonged use of the drug or an increase in dosage can cause swelling of the knee joints and arthrosis, muscle clamps and arthralgia;
other violations. These can be visual impairment and pain in the eye area, ringing in the auricle and back pain, high sweating and thirst, perversion of smell and taste buds.

and violations of liver function - conditions in which Amlodipine is prescribed with extreme caution.

To exclude complications, it is necessary to limit the use of the drug when:

when the level is below 90;
lactose intolerance;
the risk of allergic reactions to specific components;
cardiovascular insufficiency;
pregnancy;
minor age;
lactation.

The first month after a heart attack, the use of a hypertonic agent is contraindicated.

How long can I take Amlodipine without a break?

Patients are interested in whether it is worth taking Amlodipine without interruption. The list of side effects that come from uncontrolled and continuous use of the drug is very wide.

In order not to harm the body, you can not exceed the dosage of the drug. It is forbidden to start a new therapeutic course without interruption.

Composition of Amlodipine

This medication is available in the form of tablets, which contain in their composition the main active substance - amlodipine besilate. In addition to it, the medicine also contains auxiliary components, namely:

lactose; calcium stearate; croscarmellose sodium.

White, colorless coated tablets are sold in plates packed in a large cardboard box. You can buy Amlodipine at any pharmacy. For Russia, the price is approximately 40 rubles. As for Ukraine, this drug can be purchased at an average price of 15 UAH.

Instructions for use of the drug

Most often, amlodipine is used to normalize blood pressure. From what pressure should the medicine be used? It is taken by people suffering from hypertension. And also the Drug is prescribed for such diseases and ailments:

treatment of hypertension at the initial stage of development; with irregular, single jumps in blood pressure; with stable angina; with spasms of blood vessels.

Amlodipine helps lower high blood pressure and also improves the functioning of the cardiovascular system. Therefore, if the patient has a rapid heartbeat along with high blood pressure, then the drug will bring the body back to normal.

Important to remember! Before using Amlodipine, you need to consult a specialist! Only he can prescribe the drug, because self-treatment can cause complications, and with the wrong dosage, unpleasant side effects.

Features of taking Amlodipine

This medicinal product contains potent substances. Therefore, during the period of treatment with Amlodipine, it is required to adhere to the following rules:

IT IS IMPORTANT TO KNOW!

A remedy that will relieve you of HYPERTENSION in a few tricks

>>> During the reception period, weight should be monitored, as well as observed by a dentist. The medicine may cause excess weight or severe bleeding of the gums. Do not stop taking the drug abruptly. This can renew bouts of high blood pressure, and a high heart rate may also be observed. During treatment, people whose professional activity associated with increased care and responsibility, it is better to take a vacation. Since this drug causes constant drowsiness or dizziness. In patients with hepatic insufficiency, the use of amlodipine should be carried out under the regular supervision of a specialist.

The relatively low cost of the drug allows it to be used by all segments of the population. But, nevertheless, before use, you should consult a specialist.

How to use

Depending on the problems with blood pressure, the dosage is prescribed in different ways, namely:

Infrequent increase in blood pressure. You can reduce this indicator with the help of 1 tablet 1 time per day. When to take the drug, in the morning or in the evening. It is better to take the tablet in the morning, as it begins to act after a couple of hours. If there is no improvement in the condition, it is required to increase the dosage to 2 tablets per day, taking them once. With prolonged use of the drug, the dose should be reduced to 0.5 tablets per day. The course of treatment lasts 1 week. An increase in duration can only be prescribed by a specialist. Arterial hypertension. People suffering from this disease are required to take Amlodipine 0.5 tablets per day. This treatment has a supportive effect on the body. Take the drug in this mode should be constantly. Violations of the functioning of the cardiovascular system. For heart disease, experts recommend taking 1 tablet 1 time per day. If improvement is not observed for a long period of time, then you can increase the dose to 2 tablets for a while. How long should this drug be taken? Most often, doctors recommend using it on an ongoing basis for heart problems.

As an effective medicine for hypertension.

It is advised to take the drug "Hypertonium".

This is a natural remedy that acts on the cause of the disease, completely preventing the risk of getting a heart attack or stroke. Hypertension has no contraindications and begins to act within a few hours after its use. The effectiveness and safety of the drug has been repeatedly proven by clinical studies and many years of therapeutic experience.

The opinion of doctors ... "

Important to remember! The duration of treatment with Amlodipine is determined only by a specialist! The patient should regularly visit a doctor who should assess the state of health during the period of this therapy and the advisability of continuing to take the pills.

Side effects

With excessive use of this drug, a person may experience such ailments:

From the side of the cardiovascular system: swelling of the upper and lower extremities, pain in the heart, shortness of breath with minor exertion, increased or decreased heart rate. From the side of the central nervous system: rapid fatigue, dizziness with loss of consciousness, sleep disturbances, causeless irritability, anxiety, apathy. On the part of the functioning of the gastrointestinal tract: nausea with vomiting, pain in the lower part of the abdominal cavity, constipation or diarrhea, constant thirst, exacerbation of gastritis.

Also, the patient may have problems in intimate life, painful urination, allergic rashes on the skin, fever.

Important to remember! You should stick to the dosage prescribed by the doctor! This will help protect the body from the occurrence of the above side effects.

Contraindications for use

This drug is strictly contraindicated in such cases:

during pregnancy, the active component of Amlodipine adversely affects the development of the fetus; breastfeeding period; with diabetes; with low blood pressure; persons under 18 years of age; with lactose intolerance; with individual intolerance or hypersensitivity to the components of the drug.

Also, if the patient has severe allergic reactions after using Amlodipine, such treatment should be stopped and a specialist should be consulted about the use of similar drugs.

Norvasc or Amlodipine: which is better

Norvasc is a drug whose active substance is amlodipine. If we compare this imported medicine with Amlodipine, then there is no significant difference in the effect on the body. Norvasc is several times more expensive than its domestic counterpart, but the foreign drug has an advantage in terms of the degree of purification and concentration of the active substance.

A package of Norvasc costs an average of 400 rubles in Russia. In Ukraine, it can be purchased for approximately 130 UAH. Therefore, many people suffering from a regular increase in blood pressure cannot afford such treatment and choose Amlodipine.

Drug analogues

In addition to Norvasc, modern pharmacology offers many more drugs similar in composition and effect on the body, namely:

Duaktin. This drug is available in capsules. It is prescribed for hypertension, as well as for chronic heart palpitations. The advantage is the minimum number of contraindications for use. Tenox. It is used in severe forms of hypertension and chronic angina pectoris. The drug is not suitable for people suffering from acute heart failure. Normodipin. In a short time, it normalizes high blood pressure, improves the functioning of the cardiovascular system. Contraindicated in people who have had an acute myocardial infarction. Emlodin. A fairly inexpensive analogue of Amlodipine. It is strictly forbidden to use in severe hypotension, as well as in violation of the functioning of the left ventricle.

Regardless of the choice of a particular drug, high pressure, it is required to coordinate its dosage and expediency of use with a specialist.

According to statistics, about 7 million annual deaths can be attributed to high level blood pressure. But studies show that 67% of hypertensive patients do not suspect at all that they are sick! How can you protect yourself and overcome the disease? Dr. Alexander Myasnikov told in his interview how to forget about hypertension forever ...

represents

vasodilator drug

from the group of blockers of slow calcium channels, which has the ability to reduce arterial

pressure

and reduce the need of the heart muscle for oxygen, thereby preventing angina attacks. Amlodipine is effective in stopping and preventing angina attacks in people who are not helped by nitrates (nitroglycerin, etc.). Also, the drug is effective for lowering blood pressure in people who are not helped by drugs from the group of beta-blockers (Atenolol, Acebutolol, Bisoprolol, Betaxolol, Metoprolol, Nadolol, Nebivolol, Propranolol, Sotalol, Timolol, etc.).

Varieties, names, forms of release and composition of Amlodipine

Currently, Amlodipine is available in several varieties, which differ from each other only in small additional words in the names. The fact is that all varieties of the drug in the name contain the word "Amlodipine". However, to make the name unique, each pharmaceutical company or plant adds some other abbreviation to the word "Amlodipine", reflecting the short and recognizable name of the manufacturer itself, for example, "Amlodipine Teva", "Vero-Amlodipine", etc.

Currently, varieties of Amlodipine are produced under the following names:

Amlodipine; Amlodipine Agio; Amlodipine Alkaloid; Amlodipine Biocom; Amlodipine Borimed; Amlodipine Zentiva; Amlodipine ZT; Amlodipine Cardio; Amlodipine Prana; Amlodipine Sandoz; Amlodipine Teva; Amlodipine Chaikapharma. Such additional abbreviations in the names are necessary for pharmaceutical companies to register the drug they produce as a unique product, the rights to which belong only to them. This is done in connection with the peculiarities of the succession of modern pharmaceutical plants, which have become joint-stock companies, with state enterprises former USSR. The fact is that Amlodipine was developed and started to be produced back in the USSR, when it was produced by all pharmaceutical factories under the same name.

After the transition to a market economy and the privatization of enterprises, each pharmaceutical plant had a technology for the production of Amlodipine, which was left over from unified system USSR, but now it was required to make your drug unique, that is, branded. And for this, an abbreviation was added to the usual, old and well-recognized name "Amlodipine", meaning the short name of the pharmaceutical plant. But, despite the “additive” in the name, the drug remained the same Amlodipine, since it is produced according to the old technology. That is why all varieties of Amlodipine, despite different, but very similar names, are the same drug. The only difference between the varieties of Amlodipine may be in their quality: that is, the preparations of one plant are better than another, because it better adheres to the standards of production technology, uses more raw materials High Quality etc. Otherwise, there are no differences between the varieties, so in the future text of the article we will combine them under one common name "Amlodipine".

All varieties of Amlodipine are available in a single dosage form - oral tablets. As an active ingredient, the tablets contain amlodipine in three possible dosages - 2.5 mg, 5 mg or 10 mg each. In this regard, in everyday life, tablets of various dosages are often indicated by the names "Amlodipine 5", "Amlodipine 10" or "Amlodipine 2.5", where the figure corresponds to the dose of the active ingredient.

However, in the instructions for use, you can often find an indication that the tablets do not contain 5 or 10 mg of amlodipine, but 6.9 and 13.8 mg. amlodipine besilate respectively. This does not mean that the dosage of the active substance in such tablets is higher, since in fact it is 5 or 10 mg of amlodipine. The manufacturer simply indicates how much amlodipine besylate is contained in each tablet, which, of course, is slightly more, since its mass is higher. But if you recalculate how much amlodipine besilate contains pure amlodipine, then you get the most famous figures - 5 mg and 10 mg, respectively.

Amlodipine tablets from different manufacturers may contain different substances as auxiliary components. Therefore, to clarify the composition of the auxiliary components, it is always necessary to carefully read the leaflet with instructions that is attached to the package with tablets by each manufacturer. Most often as auxiliary components, the following substances are introduced into Amlodipine tablets:

Crospovidone; Lactose monohydrate; Povidone; Calcium stearate. Tablets are available in packs of 10, 20, 30, 40, 50 or 100 pieces. Tablets usually have a flat-cylindrical shape, are provided with a risk and a chamfer with different parties, and are painted in white or white-cream color.

Amlodipine + Lisinopril and Amlodipine + Valsartan

The preparations Amlodipine + Lisinopril and Amlodipine + Valsartan are separate combined drugs, which, in addition to amlodipine, include other active substances.

What is the difference between Amlodipine Teva and Amlodipine?

Amlodipine and Amlodipine Teva contain the same active substance in the same dosages, therefore, at first glance, they do not differ from each other. However, this is not true, since there are differences and sometimes very significant ones.

Amlodipine Teva mainly differs from Amlodipine in that it is produced in pharmaceutical factories in Hungary under the direction and technology of the Israeli corporation TEVA Pharmaceutical Industries, Ltd. But simply Amlodipine is produced by Russian pharmaceutical plants. Accordingly, the production technology of the same drug is significantly different, which causes all the other differences between Amlodipine Teva and Amlodipine.

Firstly, the quality of Amlodipine Teva is often higher than that of Amlodipine produced by most Russian pharmaceutical factories, which is due to several factors. For the production of Amlodipine Teva, a purer active substance with a minimum amount of impurities is used. That is, the active ingredient, before putting it into a tablet, is preliminarily purified from impurities, tested according to various parameters, and only after that it is allowed to the production line. As a result, the active substance without impurities has a more pronounced therapeutic effect, causing excellent drug efficacy and a minimum number, severity and risk of side effects. That is, by purifying the active ingredient, TEVA Pharmaceutical Industries, Ltd. It achieves both high efficiency and a small number of side effects of Amlodipine.

However, such purification and verification of the active substance is quite costly and time-consuming, and in addition, it requires a developed and tested technology. Therefore, at many Russian pharmaceutical plants, the active substance is not purified, it is immediately put into the technological cycle. And the active substances themselves, as a rule, are purchased from large chemical laboratories in India and China, which produce them in large quantities and, accordingly, different quality. The same active substance with a different amount of impurities will have a different therapeutic effect. Moreover, a substance with a smaller amount of impurities has a better therapeutic effect, and with a large amount, respectively, the worst. Thus, the effectiveness of Amlodipine will depend entirely on how pure the active substance is in it. And since costs are necessary to obtain a substance well purified from impurities, then, accordingly, the more expensive Amlodipine will be of better quality compared to the cheap one.

Thus, the main difference between Amlodipine Teva and Amlodipine is its better quality and, accordingly, higher cost. In addition, the instructions for Amlodipine Teva may indicate side effects that are absent in those for Amlodipine. However, this does not mean that Amlodipine does not cause such side effects as Amlodipine Teva. On the contrary, it causes and even much more often. Just TEVA Pharmaceutical Industries, Ltd. monitors the clinical use of Amlodipine Teva and records all emerging side effects, after which it supplements the instructions by adding them to the appropriate section. Russian manufacturers of Amlodipine do not track the appearance of side effects and, in principle, are not very interested in everything that happens with the drug in clinical use. Therefore, their instruction is written once and does not change for a long time. But this only reflects the fact that the manufacturer does not fix the properties of its drug and does not make timely amendments to the instructions.

Amlodipine - what helps? (therapeutic action)

Amlodipine blocks the work of calcium channels located on the membranes of myocardial cells and the vascular walls of the arteries. By blocking channels

does not enter the cells through the membrane, as a result of which the muscle tone of the vessels and myocardium decreases, and their relaxation occurs. Accordingly, the relaxed blood vessels become wider, which makes it easier for blood to flow through them and, thus, blood pressure decreases.

The expansion of myocardial vessels and a decrease in the tension of the muscle cells themselves leads to the fact that the heart muscle requires less oxygen for normal functioning. After all, relaxed muscles need less oxygen than tense ones. Accordingly, the myocardium acquires the ability to function normally in the presence of a small amount of oxygen. And thus, a person suffering from angina pectoris can increase exercise tolerance and reduce the frequency and severity of angina attacks.

The effect of lowering blood pressure of Amlodipine is called antihypertensive (hypotensive), and reducing myocardial oxygen demand is called antianginal. It is the hypotensive and antianginal effects that are the main effects of Amlodipine used in clinical practice.

Due to its high safety and the absence of a reflex heartbeat or a sharp decrease in pressure, amlodipine can be used to treat people suffering, in addition to angina pectoris, diabetes, gout or bronchial asthma.

Antianginal and hypotensive effects of Amlodipine provide the following action:

Expands the arteries and arterioles of the myocardium in all its parts. It is especially important that Amlodipine dilates blood vessels in areas of the myocardium suffering from ischemia (lack of oxygen). That is, the drug improves blood supply not only to normal parts of the heart muscle, but also to those whose vessels are clogged with atherosclerotic plaques; Increases the amount of oxygen supplied to myocardial cells per unit time; Reduces the degree of myocardial ischemia in angina pectoris; Reduces the load on the heart muscle; Reduces the need myocardium in oxygen to work in normal mode or with a load; Reduces the frequency of angina attacks; Reduces the amount of nitroglycerin used to stop angina attacks; Prevents vasoconstriction of the heart, including when smoking; Increases endurance and tolerance of physical and emotional stress in angina pectoris; Slows down progression of angina; Reduces the degree of myocardial hypertrophy of the left ventricle of the heart; Gently lowers blood pressure; Prevents thickening of the inner lining of the walls of the blood vessels of the heart and reduces mortality in people suffering from atherosclerosis with stenosis up to 3 or more its arteries, angina pectoris, as well as those who have undergone myocardial infarction or percutaneous angioplasty; Against the background of regular course use, it reduces the frequency of hospitalizations for unstable angina and the progression of chronic heart failure. Amlodipine does not lead to a sharp decrease in blood pressure, does not reduce exercise tolerance, does not cause a reflex heartbeat and reduces the degree of platelet aggregation.

The primary effect of Amlodipine develops 2 to 4 hours after ingestion and persists for 24 hours.

Indications for use

Amlodipine tablets are indicated for use as part of complex therapy for the following diseases of the cardiovascular system:
Arterial hypertension (the drug can be used as a monotherapy or in combination with diuretics, beta-blockers or ACE inhibitors); Angina pectoris (stable) and Printsmetal (can be used as the only drug of therapy or in combination with other antianginal drugs, for example, Riboxin , Preductal, etc.); Painless form of myocardial ischemia; Ischemic heart disease in combination with heart failure or without it; Dilated cardiomyopathy with severe chronic heart failure (Amlodipine is used as part of complex therapy).

Amlodipine - instructions for use

Dosages and duration of taking the drug

Amlodipine tablets should be taken orally, swallowed whole, without biting, breaking, chewing or otherwise crushing. The tablet should be taken with a small amount of non-carbonated

(half a glass is enough).

You can take Amlodipine regardless of food intake, since food does not affect the degree and rate of absorption of the drug into the bloodstream. Amlodipine, taken before, during or after a meal, is absorbed equally for a long time - within 2 to 3 hours, as a result of which the therapeutic effect appears 2 to 4 hours after taking the pill. The drug is taken once a day, and it is optimal to do this in the morning, so that you can monitor your own well-being, as well as evaluate the effectiveness and tolerability of Amlodipine.

With hypertension in order to lower blood pressure, amlodipine should be taken at a dose of 5 mg (1 tablet) once a day. If blood pressure does not decrease to the required limits after 1-2 weeks of taking Amlodipine 5 mg 1 time per day, then, if the drug is well tolerated, its dosage can be increased to 10 mg. Accordingly, Amlodipine should be taken already at 10 mg once a day. The drug at a dose of 10 mg once a day is taken until it is possible to achieve a stable decrease in blood pressure and keep it within normal limits without pronounced fluctuations during the day.

After that, they switch to taking Amlodipine in a maintenance dosage - 2.5 - 5 mg once a day. And at first the dose is reduced to 5 mg and taken within a week. Then reduce the maintenance dose to 2.5 mg and monitor blood pressure. If they are normal, that is, the blood pressure remains within the normal range and there are no jumps, then Amlodipine continues to be taken at a maintenance dosage of 2.5 mg continuously (for years). If the pressure, while taking 2.5 mg of Amlodipine per day, begins to rise and fall sharply, then you should return to the maintenance dosage of 5 mg per day and take the drug in this mode for a long time.

With arterial hypertension Amlodipine in maintenance dosages is taken continuously, without any interruptions. Cancellation of the drug is made by the doctor only if it has become ineffective or it is necessary to conduct a course of treatment with other drugs. In other cases, Amlodipine cannot be canceled, since the drug should be drunk constantly to maintain blood pressure levels within safe limits.

Any type of angina pectoris in order to prevent seizures and improve exercise tolerance, amlodipine should be taken at a dose of 5 mg once a day for 2 to 3 weeks. Then, if necessary, and against the background of normal tolerance, the dose of Amlodipine is increased to 10 mg per day and taken in this mode for several months to prevent angina attacks.

With dilated cardiomyopathy, combined with severe heart failure, Amlodipine begin to take 5 mg once a day for 1 to 3 weeks. After that, subject to good tolerability of the drug, the dosage is increased to 10 mg per day and taken for several months in a row. If amlodipine 10 mg per day is poorly tolerated, then the dosage should be reduced and taken at 5 mg once a day for several months.

With coronary heart disease, Amlodipine is started taking 2.5-5 mg once a day. If this dosage is sufficient, then it is not increased and the drug is continued at 5 mg once a day for several months. If the effect of Amlodipine is insufficient, then the dosage is increased to 10 mg per day and taken for several months.

The maximum allowable daily dosage of Amlodipine is 10 mg. The entire daily dose of the drug should be taken at one time, preferably in the morning. In severe liver disease, amlodipine is started at a dosage of 2.5 mg per day and increased only to 5 mg per day. With the simultaneous use of Amlodipine with diuretics, beta-blockers and ACE inhibitors, it is not necessary to reduce their dosage. It is also not necessary to reduce dosages in people over 65 years of age and suffering from renal insufficiency, however, they need to regularly determine creatinine clearance using the Rehberg test during the entire period of use of Amlodipine.

The duration of taking Amlodipine is determined by the doctor depending on the results of therapy, which are evaluated by functional stress tests, laboratory tests and various methods hardware diagnostics. Amlodipine is usually taken for a long time - for several months with heart diseases (angina pectoris, ischemia, cardiomyopathy) and several years with hypertension.

special instructions

During the entire period of use of Amlodipine, body weight and sodium intake should be monitored, for which it is necessary to observe low-salt

In addition, you should regularly visit

dentist

(once every three months) to prevent

soreness bleeding hyperplasia

With angina pectoris, the drug should be discontinued gradually in order to avoid a sharp deterioration in the condition and course of the disease.

Amlodipine should not be used to relieve hypertensive crisis and angina attack. Also, Amlodipine should not be used for therapy in the first days after myocardial infarction.

Women during the entire period of use of Amlodipine should use contraceptive methods, since the drug should not be taken during pregnancy.

People weighing less than 40 kg should take amlodipine in half dosages - 2.5 mg per day initial and 5 mg per day maintenance.

Use during pregnancy and breastfeeding

In experimental animal studies, amlodipine has been shown to negative impact to the fruit. Clinical data and experience with

pregnancy

and during

breastfeeding

in women are absent, as a result of which it is not known for certain whether Amlodipine has a negative effect on the fetus. Therefore, the use of Amlodipine during pregnancy and breastfeeding is prohibited, but theoretically possible. Use the drug during pregnancy should be only if the benefits outweigh all possible risks.

In principle, against the background of the use of Amlodipine, it is recommended to use contraceptive methods to prevent pregnancy, which can be adversely affected by the drug.

It is not known whether Amlodipine passes into breast milk. However, other drugs from the group of calcium channel blockers (for example, Nifedipine, Isradipine, Nimodipine, etc.) penetrate into breast milk. Therefore, if necessary, the use of Amlodipine should stop breastfeeding and transfer the child to artificial milk formulas.

Influence on the ability to control mechanisms

At the beginning of therapy with amlodipine, a person may experience

dizziness

and drowsiness, so it should be taken with caution by people whose work is associated with the need to have high speed reactions and concentration, for example, drivers, conveyor operators, etc. But in general, the drug can be taken by people whose work is related to the control of mechanisms.

Overdose

An overdose of Amlodipine is possible and is manifested by the following symptoms:

A pronounced decrease in blood pressure; Reflex tachycardia (a strong heartbeat, which is the more frequent, the lower the blood pressure); Excessive expansion of peripheral small vessels with the development of persistent hypotension, which can turn into shock with a fatal outcome. To eliminate an overdose, it is necessary, first of all, to wash the stomach with a weak solution of potassium permanganate. Especially effective gastric lavage within 2 hours after an overdose. Within an hour after gastric lavage, a sorbent should be taken (activated carbon, Polyphepan, Polysorb, Filtrum, Enterosgel, etc.). Subsequently, symptomatic therapy is carried out, aimed at maintaining the normal functioning of vital organs and systems. Dopamine is administered intravenously to restore the normal tone of blood vessels. And to reduce the severity of the effect on the heart, calcium gluconate is administered intravenously.

Interaction with other drugs

When amlodipine is co-administered with the following drugs

the severity of its hypotensive and antianginal effects is enhanced:

Antianginal drugs (Nitroglycerin, Riboxin, Preductal, etc.); Diuretics (Chlorthalidone, Clopamid, Xipamide, Indapamide, Hydrochlorothiazide, Meticlothiazide, Bendroflumethiazide, Polithiazide, Furosemide, Bumetanide, Piretanide, Torsemide and ethacrynic acid); ACE inhibitors (Captopril , Ramipril, Enalapril, Lisinopril, etc.); Beta-blockers (Timolol, Bisoprolol, Celiprolol, Metoprolol, Sotalol, Atenolol, Propranolol, Nebivolol, etc.); ); Alpha1-blockers (Alfuzosin, Tamsulosin, Omnik, Revokarin, Fokusin, Prazosin, Doxazosin, Artezin, Zoxon, Kamiren, Kardura, Tonocardin, Terazosin, Kornam, Setegis) - only the hypotensive effect is enhanced; Antipsychotics (Aminazin, Tizercin, Nozinan, Etaperazin, Triftazin, Stelazin, Fluorphenazine, Moditen, Sonapax, Piportil, Haldol, Halofen, Trancodol, Truxal, Azaleptin, Leponex, Zyprexa, Rispolept, Semap, Pimozide) - only the hypotensive effect is enhanced; Amiodarone - only the hypotensive effect is enhanced. Reduce the severity of the hypotensive effect of Amlodipine, which can provoke a sharp increase in blood pressure with the subsequent development of a hypertensive crisis, the following drugs:

Sympathomimetics (Epinephrine, Norepinephrine, Midodrine, Phenylephrine, Dobutamine) , Enfluran, Isofloran, Thiopental-sodium, Propofol, Ketamine, Propanidide, nitrous oxide, etc.); Amlodipine in rare cases can cause an increase in the effect of antiarrhythmic drugs.

Calcium preparations reduce the severity of the therapeutic effect of Amlodipine.

Simultaneous administration of Amlodipine at a dosage of 10 mg and Simvastatin at a dose of 80 mg increases the degree of absorption of the latter drug by 77%. Therefore, in such cases, the dosage of Simvastatin should be reduced to 20 mg.

A single dose of 100 mg of Sildenafil (Viagra) or alcohol does not affect the therapeutic effects of Amlodipine in people suffering from arterial hypertension.

Antiviral drugs (Ritonavir, Tamiflu, Acyclovir, Ganciclovir, etc.) increase the concentration of Amlodipine in the blood plasma.

With the simultaneous administration of Amlodipine with lithium salts, nausea, vomiting, diarrhea, ataxia (impaired coordination of movements), trembling of the extremities and tinnitus may occur.

Vero-Amlodipine and Amlodipine Prana - instructions for use

Instructions for use of any variety of Amlodipine, including Vero-Amlodipine and Amlodipine Prana, are given in the section above. Vero-Amlodipine and Amlodipine Prana do not have any features, therefore they are used according to the above rules.

Side effects

Amlodipine can cause the following side effects from various organs and systems:

1. The cardiovascular system:

Palpitations (tachycardia); Bradycardia (decrease in heart rate); Rhythm disturbance (arrhythmia); Hypotension (low blood pressure), including when moving from a sitting or lying position to standing; Chest pain; Redness of the skin of the face (hot flashes) ; Extrasystole; Migraines. 2. Nervous system:

Fatigue; Headache; Dizziness; Drowsiness; Fatigue; Asthenia; Mood swings; Convulsions; Fainting; Tremors of the limbs; Malaise; Insomnia; Nervousness; Depression; . 3. Urogenital system:

Swelling in the ankles and feet; Increased frequency of urination; Impotence; Painful urge to urinate; Pollakiuria (urination in small portions, literally drop by drop); Nocturia (frequent urination at night). 4. Digestive tract:

Nausea; Vomiting; Abdominal pain; Change in the frequency and habitual mode of bowel movement; Constipation; Diarrhea; Jaundice; Dyspeptic symptoms (belching, flatulence, feeling of heaviness in the abdomen, etc.); Dry mouth; Anorexia; Gastritis; ;Pancreatitis. 5. Respiratory system:

Dyspnea. 6. Musculoskeletal system:

Arthralgia (pain in the joints); Myalgia (pain in the muscles); Arthrosis; Myasthenia gravis (muscle weakness); Pain in the extremities; Paresthesia (numbness, tingling sensation, "goosebumps", etc.). 7. Skin covers:

Xeroderma; Alopecia (baldness); Dermatitis; Purpura. 8. Allergic reactions:

Skin rash; Skin itching; Erythema multiforme. 9. Other:
Hyperplasia of the gums; Gynecomastia; Visual impairment; Conjunctivitis; Pain in the eyes; Double vision; Xerophthalmia; Ringing in the ears; Back pain; Chills; Weight gain; sticky sweat; Cough; Runny nose; Taste perversion; Parosmia (impaired sense of smell, olfactory hallucinations); Hyperglycemia (increased blood glucose level); Increased activity of liver enzymes - AsAT, AlAT, alkaline phosphatase.

Contraindications for use

Currently, doctors and scientists identify relative and absolute contraindications to the use of Amlodipine. Absolute contraindications include diseases and conditions in which the use of Amlodipine is strictly prohibited. Relative conditions include conditions in which Amlodipine can be used with caution under the close supervision of a physician.

Absolute contraindications to receive Amlodipine are the following diseases and conditions:

Severe hypotension (systolic pressure below 90 mm Hg); Collapse; Cardiogenic shock; Unstable angina (except Prinzmetal's angina); Aortic stenosis; Pregnancy and breastfeeding; Age under 18 years; Lactase deficiency, lactose intolerance and glucose-galactose malabsorption; Hypersensitivity or allergic reactions to any components of Amlodipine; Allergic reactions to dihydropyridine derivatives (Nifedipine, Isradipine, Nimodipine, etc.). Relative contraindications to receive Amlodipine are the following conditions:
Dysfunction of the liver; Syndrome of weakness of the sinus node; Chronic heart failure of non-ischemic origin of III-IV classes according to the NYNA classification; Arterial hypotension (low blood pressure); Aortic stenosis (narrowing of the aortic lumen); Mitral stenosis (narrowing of the mitral valve); Hypertrophic obstructive cardiomyopathy; Acute myocardial infarction (within a month after a heart attack); Liver failure; Old age over 65 years.

Amlodipine - analogues

In the modern pharmaceutical market, Amlodipine analogues include two groups of drugs - synonyms and, in fact, analogues. Synonyms are drugs that also contain amlodipine as an active substance. Analogues are drugs from the group of slow calcium channel blockers, which have similar effects to Amlodipine, but contain other active substances.

To the synonyms of Amlodipine include the following drugs:

Agen; Amlo; Amlovas; Amlodak; Amlodigamma; Amlodil; Amlodipharm; Amlocard-Sanovel; Amlong; Amlonorm; Amlorus; Amlotop; Kalchek; . Analogues of Amlodipine are the following drugs:
Adalat solution for infusion; Adalat SR tablets; Zanidip-Recordati tablets; Zanifed capsules; Calcigard retard tablets; Cordafen tablets; Cordaflex and Cordaflex RD tablets; Cordipin, Cordipin retard, Cordipin HL tablets; Corinfar, Corinfar retard and Corinfar UNO tablets; Lacipil tablets ;Lerkamen 10 and Lerkamen 20 tablets;Nicardia tablets;Nimopin tablets and solution for infusion;Nimotop tablets and solution for infusion;Nifedicap capsules;Nifedipine dragee, tablets;Nifecard XL tablets;Octidipine tablets;Osmo-Adalat tablets;Plendil tablets;Sakur tablets ;Felodip tablets;Felodipine tablets;Felotenz retard tablets;Fenigidin tablets;Foridon tablets and injection solution;EsCordi Core tablets.

Amlodipine - reviews

Most of the reviews about Amlodipine (from 80% to 90%) are positive, due to a noticeable positive effect on the current

heart disease

or arterial hypertension. In most cases, people take amlodipine for hypertension in order to reduce and maintain pressure within normal limits. The reviews indicate that the drug gently and effectively reduces

blood pressure

Eliminates noise in the head, is well tolerated and allows you to maintain performance and good health. The advantages that distinguish Amlodipine from other antihypertensive drugs are considered by people to be several characteristics of the drug - firstly, it is the ability to use the elderly, and secondly, the convenience of taking (once a day) and the duration of the therapeutic effect.

Negative reviews about Amlodipine are few and due to two main factors - inefficiency in this particular case and poor tolerability due to the severity of side effects. Most often in negative feedback it is noted that amlodipine causes drowsiness, lethargy and apathy, which are very poorly tolerated, because they do not allow a person to lead a normal life.

Amlodipine - price

The cost of amlodipine can vary significantly depending on the manufacturer of the drug. So, drugs produced by the Israeli corporation Teva or the Swiss Sandoz are quite expensive, and Amlodipine, produced by Russian pharmaceutical plants, on the contrary, is very cheap. Unfortunately, the quality and effectiveness of amlodipine from different manufacturers also vary greatly. Therefore, if Amlodipine of any manufacturer turned out to be ineffective or provoked side effects, then it makes sense to purchase a drug from another company, since it can be an excellent medicine.

Currently, the cost of Amlodipine from various manufacturers in pharmacies in Russian cities varies within the following limits:

Tablets 5 mg, 20 pieces - 51 - 109 rubles; Tablets 5 mg, 30 pieces - 34 - 209 rubles; Tablets 5 mg, 60 pieces - 83 - 124 rubles; Tablets 5 mg, 90 pieces - 113 - 174 rubles; Tablets 10 mg, 20 pieces - 71 - 167 rubles; Tablets 10 mg, 30 pieces - 60 - 281 rubles; Tablets 10 mg, 60 pieces - 113 - 128 rubles; Tablets 10 mg, 90 pieces - 184 - 226 rubles.

ATTENTION! The information posted on our site is a reference or popular and is provided to a wide range of readers for discussion. The prescription of medicines should be carried out only by a qualified specialist, based on the history of the disease and the results of the diagnosis.

Amlodipine is a cellular calcium channel blocker. Calcium ions are active participants in a number of bioenergetic processes occurring in the cells of the human body. However, their increased concentration is not a positive circumstance, rather the opposite: there is an excessive intensification of cellular metabolism processes that require an excess amount of oxygen. Such work of the cell "for wear and tear" can trigger a number of undesirable destructive changes. Amlodipine, preventing the penetration of calcium ions into the cell, is a kind of controller that maintains the biochemical balance in the extra- and intracellular space at the proper level.

One of the main advantages of amlodipine is its pronounced antianginal effect: it dilates the coronary and peripheral blood vessels, which significantly unloads the heart muscle, reduces its oxygen demand, and reduces vascular resistance, which is especially important for angina pectoris and ischemia. Another advantage of amlodipine, widely used by cardiologists in relation to their patients, is its persistent hypotensive effect, due to the same vasodilating effect of the drug. For example, in people with arterial hypertension, even a single dose of amlodipine provides a noticeable, and at the same time, a smooth decrease in pressure for a period of up to 24 hours.

Amlodipine is taken at any time, regardless of the patient's diet. In order to prevent an attack of angina pectoris and to treat hypertension, the initial dose of amlodipine is 5 mg per day, taken at a time. Depending on the observed effect, the dose can be doubled (but no more). Cardiologists advise to establish a clear schedule for taking amlodipine and in the future try to stick to it, taking the drug at the same time. As part of combined pharmacotherapy while taking other cardiac drugs (ACE inhibitors, beta-blockers, etc.), dose adjustment of amlodipine is not required.

Patients with unimpressive dimensions, as well as those suffering from liver diseases, take smaller doses of the drug. But people suffering from renal insufficiency, or the elderly take amlodipine on a general basis. The amlodipine withdrawal syndrome present in certain drugs of the cardiac group is not characteristic, however, a gradual decrease in the doses of the drug is recommended before stopping the course of treatment. Patients suffering from diseases such as gout, bronchial asthma or diabetes mellitus can take amlodipine without any restrictions: it does not has a negative effect on blood lipids and does not affect metabolism.

Pharmacology

Selective calcium channel blocker class II. The antihypertensive effect is due to a direct relaxing effect on vascular smooth muscle. It is assumed that the antianginal effect of amlodipine is associated with its ability to expand peripheral arterioles; this leads to a decrease in OPSS, while reflex tachycardia does not occur. As a result, there is a decrease in myocardial oxygen demand and energy consumption by the heart muscle. On the other hand, amlodipine appears to dilate large coronary arteries and coronary arterioles in both intact and ischemic areas of the myocardium. This ensures the supply of oxygen to the myocardium during spasms of the coronary arteries.

Pharmacokinetics

When taken orally, it is absorbed from the gastrointestinal tract slowly and almost completely, C max in blood plasma is reached within 6-9 hours. Protein binding is 95-98%. It undergoes minimal metabolism during the first passage through the liver and slow but significant hepatic metabolism with the formation of metabolites with little pharmacological activity.

T 1 / 2 averages 35 hours and with arterial hypertension can increase to an average of 48 hours, in elderly patients - up to 65 hours and with impaired liver function - up to 60 hours. Excreted mainly as metabolites: 59-62% - kidneys, 20-25% - through the intestines.

Release form

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
30 pcs. - polymer bottles (1) - cardboard packs.
100 pieces. - polymer cans (1) - packs of cardboard.
100 pieces. - polymer bottles (1) - cardboard packs.

Dosage

For adults, when taken orally, the initial dose is 5 mg 1 time / day. If necessary, the dose may be increased.

Maximum dose: when taken orally - 10 mg / day.

Interaction

It is possible to enhance the antianginal and antihypertensive action of slow calcium channel blockers when used together with thiazide and "loop" diuretics, ACE inhibitors, beta-blockers and nitrates, as well as to enhance their antihypertensive action when used together with alpha 1 -blockers, antipsychotics.

Although a negative inotropic effect has not generally been observed with amlodipine, however, some slow calcium channel blockers may increase the negative inotropic effect of antiarrhythmic agents that cause QT interval prolongation (eg, amiodarone and quinidine).

Simultaneous repeated use of amlodipine at a dose of 10 mg and simvastatin at a dose of 80 mg leads to an increase in the bioavailability of simvastatin by 77%. In such cases, the dose of simvastatin should be limited to 20 mg.

Antiviral drugs (for example, ritonavir) increase plasma concentrations of slow calcium channel blockers, incl. amlodipine.

With the simultaneous use of sympathomimetics, estrogens, it is possible to reduce the antihypertensive effect due to sodium retention in the body.

Antipsychotics and isoflurane enhance the antihypertensive effect of dihydropyridine derivatives. With the simultaneous use of drugs for inhalation anesthesia, an increase in the hypotensive effect is possible.

With the simultaneous use of amiodarone, an increase in the antihypertensive effect is possible.

With the simultaneous use of lithium carbonate, manifestations of neurotoxicity (including nausea, vomiting, diarrhea, ataxia, trembling and / or tinnitus) are possible.

With simultaneous use, orlistat reduces the antihypertensive effect of amlodipine, which can lead to a significant increase in blood pressure, the development of a hypertensive crisis.

With the simultaneous use of indomethacin and other NSAIDs, it is possible to reduce the antihypertensive effect of amlodipine due to inhibition of prostaglandin synthesis in the kidneys and fluid retention under the influence of NSAIDs.

With the simultaneous use of quinidine, an increase in the antihypertensive effect is possible.

Calcium preparations can reduce the effect of slow calcium channel blockers.

With the simultaneous use of diltiazem (an inhibitor of the CYP3A4 isoenzyme) at a dose of 180 mg and amlodipine at a dose of 5 mg in elderly patients (from 69 to 87 years old) with arterial hypertension, there is an increase in the bioavailability of amlodipine by 57%. The simultaneous use of amlodipine and erythromycin in healthy volunteers (from 18 to 43 years old) does not lead to significant changes in the exposure of amlodipine (increase in AUC by 22%). Although the clinical significance of these effects is not entirely clear, they may be more pronounced in elderly patients. Potent inhibitors of the CYP3A4 isoenzyme (eg, ketoconazole, itraconazole) can lead to an increase in plasma concentrations of amlodipine to a greater extent than diltiazem. Amlodipine and inhibitors of the CYP3A4 isoenzyme should be used with caution.

There are no data on the effect of inducers of the CYP3A4 isoenzyme on the pharmacokinetics of amlodipine. Blood pressure should be carefully monitored while using amlodipine and inducers of the CYP3A4 isoenzyme.

Side effects

From the side of the cardiovascular system: peripheral edema, tachycardia, hyperemia of the skin; when used in high doses - arterial hypotension, arrhythmias, shortness of breath.

From the digestive system: nausea, abdominal pain; rarely - gingival hyperplasia.

From the side of the central nervous system and peripheral nervous system: headache, fatigue, drowsiness, dizziness; with prolonged use - paresthesia.

Allergic reactions: skin rash, itching.

Others: with prolonged use - pain in the limbs.

Indications

Arterial hypertension (as monotherapy or as part of combination therapy).

Stable angina, unstable angina, Prinzmetal's angina (as monotherapy or as part of combination therapy).

Contraindications

Severe arterial hypotension (systolic blood pressure less than 90 mm Hg); obstruction of the outflow tract of the left ventricle (including severe aortic stenosis); hemodynamically unstable heart failure after myocardial infarction; children and adolescents under 18 years of age (efficacy and safety have not been established); Hypersensitivity to amlodipine and other dihydropyridine derivatives.

Application features

Use during pregnancy and lactation

The safety of amlodipine during pregnancy has not been established, therefore, use is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

There are no data indicating the excretion of amlodipine in breast milk. However, other slow calcium channel blockers (dihydropyridine derivatives) are known to be excreted in breast milk. In this regard, if necessary, the use of amlodipine during lactation should decide on the termination of breastfeeding.

Application for violations of liver function

Use with caution in violations of liver function.

Application for violations of kidney function

Use with caution in violations of kidney function.

Use in children

special instructions

Caution should be used in patients with liver failure, chronic heart failure of non-ischemic etiology III-IV functional class according to the NYHA classification, unstable angina pectoris, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and within 1 month after it), SSSU (severe tachycardia, bradycardia), arterial hypotension, with simultaneous use with inhibitors or inducers of the CYP3A4 isoenzyme.

Against the background of the use of amlodipine in patients with chronic heart failure (class III and IV according to the NYHA classification) of non-ischemic origin, there was an increase in the incidence of pulmonary edema, despite the absence of signs of worsening heart failure.

In elderly patients, T 1/2 may increase and the clearance of amlodipine may decrease. Dose changes are not required, but more careful monitoring of patients in this category is necessary.

The efficacy and safety of amlodipine in hypertensive crisis has not been established.

Despite the absence of withdrawal symptoms in slow calcium channel blockers, it is desirable to discontinue treatment with amlodipine gradually.

Clinical data on the use of amlodipine in pediatrics are not available.

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Amlodipine represents vasodilator drug from the group of blockers of slow calcium channels, which has the ability to lower blood pressure and reduce the need for oxygen in the heart muscle, thereby preventing angina attacks. Amlodipine is effective in stopping and preventing angina attacks in people who are not helped by nitrates (nitroglycerin, etc.). Also, the drug is effective for lowering blood pressure in people who are not helped by drugs from the group of beta-blockers (Atenolol, Acebutolol, Bisoprolol, Betaxolol, Metoprolol, Nadolol, Nebivolol, Propranolol, Sotalol, Timolol, etc.).

Varieties, names, forms of release and composition of Amlodipine

Currently, Amlodipine is available in several varieties, which differ from each other only in small additional words in the names. The fact is that all varieties of the drug in the name contain the word "Amlodipine". However, to make the name unique, each pharmaceutical company or plant adds some other abbreviation to the word "Amlodipine", reflecting the short and recognizable name of the manufacturer himself, for example, "Amlodipine Teva", "Vero-Amlodipine", etc. Currently, varieties of Amlodipine are produced under the following names:

Amlodipine;
Amlodipine Agio;
Amlodipine Alkaloid;
Amlodipine Biokom;
Amlodipine Borimed;
Amlodipine Zentiva;
Amlodipine RT;
Amlodipine Cardio;
Amlodipine Prana;
Amlodipine Sandoz;
Amlodipine Teva;
Amlodipine Chaikapharma.

Such additional abbreviations in the names are necessary for pharmaceutical companies to register the drug they produce as a unique product, the rights to which belong only to them. This is done in connection with the peculiarities of the succession of modern pharmaceutical plants that have become joint-stock companies with state enterprises of the former USSR. The fact is that Amlodipine was developed and started to be produced back in the USSR, when it was produced by all pharmaceutical factories under the same name.

After the transition to a market economy and the privatization of enterprises, each pharmaceutical plant had the technology for the production of Amlodipine, which remained from the unified system of the USSR, but now it was required to make their drug unique, that is, branded. And for this, an abbreviation was added to the usual, old and well-recognized name "Amlodipine", meaning the short name of the pharmaceutical plant. But, despite the "additive" in the name, the drug remained the same Amlodipine, since it is produced according to the old technology. That is why all varieties of Amlodipine, despite different, but very similar names, are the same drug. The only difference between the varieties of Amlodipine may be in their quality: that is, the preparations of one plant are better than another, because it better adheres to the standards of production technology, uses higher quality raw materials, etc. Otherwise, there are no differences between the varieties, so in the future text of the article we will combine them under one common name "Amlodipine".

Crospovidone;
lactose monohydrate;
calcium stearate.

Tablets are available in packs of 10, 20, 30, 40, 50 or 100 pieces. Tablets are usually flat-cylindrical, scored and beveled on different sides, and are white or off-white in color.

Amlodipine + Lisinopril and Amlodipine + Valsartan

The preparations Amlodipine + Lisinopril and Amlodipine + Valsartan are separate combined drugs, which, in addition to amlodipine, include other active substances.

What is the difference between Amlodipine Teva and Amlodipine?

However, such purification and verification of the active substance is quite costly and time-consuming, and in addition, it requires a developed and tested technology. Therefore, at many Russian pharmaceutical plants, the active substance is not purified, it is immediately put into the technological cycle. And the active substances themselves, as a rule, are purchased from large chemical laboratories in India and China, which produce them in large quantities and, accordingly, of different quality. The same active substance with a different amount of impurities will have a different therapeutic effect. Moreover, a substance with a smaller amount of impurities has a better therapeutic effect, and with a large amount, respectively, the worst. Thus, the effectiveness of Amlodipine will depend entirely on how pure the active substance is in it. And since costs are necessary to obtain a substance well purified from impurities, then, accordingly, the more expensive Amlodipine will be of better quality compared to the cheap one.

Amlodipine - what helps? (therapeutic action)

Amlodipine blocks the work of calcium channels located on the membranes of myocardial cells and the vascular walls of the arteries. Due to the blocking of the channels, calcium does not enter the cells through the membrane, as a result of which the muscle tone of the vessels and myocardium decreases, and their relaxation occurs. Accordingly, the relaxed blood vessels become wider, which makes it easier for blood to flow through them and, thus, blood pressure decreases.

Due to the high safety and the absence of a reflex heartbeat or a sharp decrease in pressure, amlodipine can be used to treat people suffering, in addition to angina pectoris, diabetes mellitus, gout or bronchial asthma.
Antianginal and hypotensive effects of Amlodipine provide the following action:

Expands the arteries and arterioles of the myocardium in all its parts. It is especially important that Amlodipine dilates blood vessels in areas of the myocardium suffering from ischemia (lack of oxygen). That is, the drug improves the blood supply not only to the normal parts of the heart muscle, but also to those whose vessels are clogged with atherosclerotic plaques;
Increases the amount of oxygen supplied to myocardial cells per unit time;
Reduces the degree of myocardial ischemia in angina pectoris;
Reduces the load on the heart muscle;
Reduces myocardial oxygen demand for normal work or exercise;
Reduces the frequency of angina attacks;
Reduces the amount of nitroglycerin used to stop angina attacks;
Prevents vasoconstriction of the heart, including smoking;
Increases endurance and tolerance of physical and emotional stress in angina pectoris;
Slows down the progression of angina pectoris;
Reduces the degree of myocardial hypertrophy of the left ventricle of the heart;
Gently lowers blood pressure;
Prevents thickening of the inner lining of the walls of the blood vessels of the heart and reduces mortality in people suffering from atherosclerosis with stenosis of up to 3 or more arteries, angina pectoris, as well as those who have had myocardial infarction or percutaneous angioplasty;
Against the background of regular course use, it reduces the frequency of hospitalizations for unstable angina and the progression of chronic heart failure.

Amlodipine does not lead to a sharp decrease in blood pressure, does not reduce exercise tolerance, does not cause a reflex heartbeat and reduces the degree of platelet aggregation.

The primary effect of Amlodipine develops 2 to 4 hours after ingestion and persists for 24 hours.

Indications for use

Amlodipine tablets are indicated for use as part of complex therapy for the following diseases of the cardiovascular system:

Arterial hypertension (the drug can be used as a monotherapy or in combination with diuretics, beta-blockers or ACE inhibitors);
Angina pectoris (stable) and Prinzmetal (can be used as the only drug of therapy or in combination with other antianginal drugs, for example, Riboxin, Preductal, etc.);
Painless form of myocardial ischemia;
Ischemic heart disease with or without heart failure;
Dilated cardiomyopathy with severe chronic heart failure (Amlodipine is used as part of complex therapy).